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In the case of deficiency of these enzymes (due to gene polymorphisms, or acquired by events such as viral infections, as in HIV infection), these accumulated arene-oxide intermediates act as haptens, stimulating the immune response or binding to tissue macromolecules and causing direct cell damage

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The cowl neckline and graceful V-back offer a balance of modesty and charm, while the subtle high-low skirt flows effortlessly with every step

Unfortunately, it wasn't the American designer's excellent cut that made news, but instead the history-making Obama's arms, which had become a talking point at the time