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If a creature with persist that has +1/+1 counters on it receives enough -1/-1 counters to cause it to be destroyed by lethal damage or put into its owner's graveyard for having 0 or less toughness, persist won't trigger and the card won't return to the battlefield
![one piece card game sakazuki Shop OP02-099 SR TCGHOBBY Product Details [On Play] You may trash 1 card from your hand One Piece Trading Card Game](https://tcgplayer-cdn.tcgplayer.com/product/527011_in_1000x1000.jpg)
Even if it dies to removal, you basically got two mana counterspell out of it that protects your other creatures from being killed
![one piece card game sakazuki Shop OP02-099 SR TCGHOBBY Product Details [On Play] You may trash 1 card from your hand One Piece Trading Card Game](https://i.redd.it/jj2bit9hm3mc1.png)
For example, a creature might have deathtouch to guarantee it trades with a creature with high power, or it might have a way to deal burn damage throughout a game
![one piece card game sakazuki Shop OP02-099 SR TCGHOBBY Product Details [On Play] You may trash 1 card from your hand One Piece Trading Card Game](https://i.ebayimg.com/images/g/TP0AAOSwmP1kVG7B/s-l1200.jpg)
Set booster boxes have 30 packs
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